癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LRRC67 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q7Z4L9 |
| Other Accession | Q7Z4L9 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35480 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LRRC67 |
| Epitope Specificity | 201-300/355 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 7 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. |
| SUBUNIT | Interacts with PPP1CC isoform gamma-2;the interaction is direct. Interacts with actin, dynein, KIF5B, KIFC1 and tubulin. Associates with microtubules. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Gene ID | 286187 |
|---|---|
| Other Names | LRRC67; TLLR; TLRR; dtr; PPR42_HUMAN; PPP1R42; Leucine-rich repeat-containing protein 67; protein phosphatase 1 regulatory subunit 42; leucine rich repeat containing 67; protein phosphatase 1, regulatory subunit 42; testis leucine-rich repeat |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PPP1R42 (HGNC:33732) |
|---|---|
| Synonyms | LRRC67 |
| Function | Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis. |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8R1Z4}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8R1Z4} Note=Colocalizes with alpha tubulin to the manchette of developing spermatids. Detected to nuclear rim in pachytene spermatocytes Detected at nuclear surface, opposite the acrosome in elongating spermatids. Detected at the microtubule-organizing center (MTOC) Localized to the centrosomal region of late-stage spermatids (By similarity). {ECO:0000250|UniProtKB:Q8R1Z4} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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