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GDE3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9HCC8 |
| Other Accession | Q9HCC8 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61729 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GDPD2/GDE3 |
| Epitope Specificity | 201-300/539 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the glycerophosphoryl diester phosphodiesterase family. Contains 1 GDPD domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | GDE3, also known as glycerophosphodiester phosphodiesterase 3, glycerophosphodiester phosphodiesterase domain containing 2 (GDPD2) or osteoblast differentiation promoting factor (OBDPF), is a 539 amino acid protein belonging to the glycerophosphoryl diester phosphodiesterase family. Possessing glycerophosphoinositol inositolphosphodiesterase activity, GDE3 hydrolyzes glycerophosphoinositol to form inositol 1-phosphate and glycerol, and is suggested to play a role in Actin cytoskeleton remodeling and osteoblast differentiation and growth. A multi-pass membrane protein, GDE3 localizes to cell membrane and cytoplasm, and colocalizes with actin in the cytoskeleton. GDE3 contains one GDPD domain, binds calcium as a cofactor and is encoded by a gene mapping to human chromosome Xq13.1. |
| Gene ID | 54857 |
|---|---|
| Other Names | GDE3; OBDPF; GDPD2_HUMAN; GDPD2; Glycerophosphodiester phosphodiesterase 3; Glycerophosphodiester phosphodiesterase domain-containing protein 2; Osteoblast differentiation promoting factor; 3.1.4.43; glycerophosphodiester phosphodiesterase domain containing 2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:50-200,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GDPD2 (HGNC:25974) |
|---|---|
| Function | Calcium-dependent ecto-phospholipase C that cleaves the phosphodiester bond between the glycerol backbone and phosphate group of glycerophospholipids at the cell surface, regulating multiple signaling pathways (PubMed:28849762, PubMed:32629025, PubMed:32917725). Substrates include GPI-anchored proteins, which are released from the membrane upon cleavage of the inositol-phosphate linkage. For example, cleavage and release of UPAR/PLAUR regulates cell-matrix adhesion and extracellular matrix remodeling (PubMed:28849762). Also cleaves the glycosylphosphatidylinositol (GPI) anchor of metalloproteases TRABD2A and TRABD2B, releasing them from the plasma membrane. This release modulates their regulation of Wnt signaling (PubMed:35182431). Also hydrolyzes lysophosphatidylinositol (LPI) to monoacylglycerol and inositol-1-phosphate. Converts 2-arachidonoyl-LPI, the endogenous GPR55 agonist, into 2-arachidonoylglycerol (2-AG), an endocannabinoid that activates CNR1/CNR2. Thereby, acts as a switch redirecting signaling from GPR55 to CNR1/CNR2 within the endocannabinoid system that could alternatively regulate osteoblast proliferation and differentiation (PubMed:32629025, PubMed:32917725). Can also cleave glycerophosphoinositol to glycerol and inositol-1-phosphate in vitro (By similarity). May also play a role in remodeling of the actin cytoskeleton (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Colocalizes with the actin cytoskeleton. {ECO:0000250|UniProtKB:Q9ESM6} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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