癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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EGFLAM Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q63HQ2 |
| Other Accession | Q63HQ2 |
| Predicted | Rat, Human, Mouse, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 111271 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Pikachurin |
| Epitope Specificity | 111-210/1017 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 3 EGF-like domains. Contains 2 fibronectin type-III domains. Contains 3 laminin G-like domains. |
| SUBUNIT | Interacts with DAG1 alpha-dystroglycan |
| Post-translational modifications | O-glycosylated; contains chondroitin sulfate and heparan sulfate. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | EGFLAM is a 1,017 amino acid secreted protein containing three EGF-like domains, two fibronectin type-III domains, and three laminin G-like domains. Colocalizing with bassoon, CtBP and dystroglycan in photoreceptor synaptic terminals, EGFLAM is involved in retinal photoreceptor ribbon synapse formation. EGFLAM may also promote matrix assembly and cell adhesion. Existing as five alternatively spliced isoforms, the gene encoding EGFLAM maps to human chromosome 5p13.2. Chromosome 5 makes up approximately 6% of the human genome and contains 181 million base pairs, which encode 1,000 genes. Cockayne syndrome, Treacher Collins syndrome, acute myelogenous leukemias and myelodysplastic syndrome are associated with genes present on chromosome 5. |
| Gene ID | 133584 |
|---|---|
| Other Names | AGRINL; AGRNL; PIKA; 5930412K08; RGD1306592; EGFLA_BOVIN; EGFLAM; EGF-like, fibronectin type-III and laminin G-like domain-containing protein; EGFLA_HUMAN; Agrin-like protein; EGFLA_MOUSE; Nectican; EGFLA_RAT; EGF like, fibronectin type III and laminin G domains; EGF-like, fibronectin type III and laminin G domains; pikachurin; agrin-like |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | EGFLAM |
|---|---|
| Synonyms | AGRINL, AGRNL, PIKA |
| Function | Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Plays a key role in the synaptic organization of photoreceptors by mediating transsynaptic interaction between alpha-dystroglycan and GPR179 on the postsynaptic membrane. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness. |
| Cellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q4VBE4}. Synaptic cleft {ECO:0000250|UniProtKB:Q4VBE4}. Presynaptic active zone {ECO:0000250|UniProtKB:Q4VBE4}. Note=Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals. {ECO:0000250|UniProtKB:Q4VBE4} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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