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CDC14B Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O60729 |
| Other Accession | O60729 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56802 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CDC14B |
| Epitope Specificity | 65-160/498 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. |
| SUBUNIT | Interacts with FZR1/CDH1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]. |
| Gene ID | 8555 |
|---|---|
| Other Names | CDC14B3; Cdc14B1; Cdc14B2; hCDC14B; 2810432N10Rik; A530086E13Rik; CC14B_HUMAN; CDC14B; CDC14 cell division cycle 14 homolog B; 3.1.3.16; 3.1.3.48; CC14B_MOUSE; cell division cycle 14B; CDC14 (cell division cycle 14, S. cerevisiae) homolog B; CDC14 cell division cycle 14 homolog B (S. cerevisiae) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CDC14B |
|---|---|
| Function | Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. |
| Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1 |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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