癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Neuroligin 3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9NZ94 |
| Other Accession | Q9NZ94 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 93895 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Neuroligin 3 |
| Epitope Specificity | 601-700/848 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the type-B carboxylesterase/lipase family. |
| SUBUNIT | Interacts with NRXN1, NRXN2 and NRXN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Homodimer, and heterodimer with NLGN1 and NLGN2. |
| DISEASE | Defects in NLGN3 may be the cause of susceptibility to autism X-linked type 1 (AUTSX1) [MIM:300425]. AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN3 may be the cause of susceptibility to X-linked Asperger syndrome 1 (ASPGX1) [MIM:300494]. ASPGX1 is considered to be a form of childhood autism. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]. |
| Gene ID | 54413 |
|---|---|
| Other Names | HNL3; A230085M13Rik; NL3; NLG3; NLGN3_HUMAN; NLGN3; Gliotactin homolog; KIAA1480; NLGN3_MOUSE; NLGN3_RAT; neuroligin 3 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NLGN3 |
|---|---|
| Synonyms | KIAA1480, NL3 |
| Function | Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8BYM5}; Single-pass type I membrane protein. Synapse {ECO:0000250|UniProtKB:Q8BYM5}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BYM5}. Note=Detected at both glutamatergic and GABAergic synapses. Localizes to dendritic membrane {ECO:0000250|UniProtKB:Q8BYM5} |
| Tissue Location | Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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