癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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ME1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P48163 |
| Other Accession | P48163 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 64150 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NADP ME |
| Epitope Specificity | 451-550/572 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the malic enzymes family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ME1 is a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. |
| Gene ID | 4199 |
|---|---|
| Other Names | HUMNDME; MES; D9Ertd267e; Mdh-1; Mod-1; Mod1; MAOX_HUMAN; ME1; NADP-ME; Malic enzyme 1; 1.1.1.40; MAOX_MOUSE; MAOX_RAT; malic enzyme 1, NADP(+)-dependent, cytosolic; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); NADP-dependent malic enzyme |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ME1 (HGNC:6983) |
|---|---|
| Function | Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in all tissues tested including liver, placenta and white adipose tissue. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97836
