癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
C20orf19 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q2M2Z5 |
| Other Accession | Q2M2Z5 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 75111 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KIZUNA/C20orf19 |
| Epitope Specificity | 1-100/673 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the kizuna family. |
| SUBUNIT | Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2. |
| Post-translational modifications | Phosphorylation at Thr-379 by PLK1 is not needed forcentrosomal localization or pericentriolar material expansion butis indispensable for spindle-pole stabilization. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf19 gene product has been provisionally designated C20orf19 pending further characterization. |
| Gene ID | 55857 |
|---|---|
| Other Names | C20orf19; HT013; Kizuna; NCRNA00153; PLK1S1; RP69; KIZ_HUMAN; KIZ; Polo-like kinase 1 substrate 1; kizuna centrosomal protein; non-protein coding RNA 153; chromosome 20 open reading frame 19 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KIZ |
|---|---|
| Synonyms | C20orf19, NCRNA00153, PLK1S1 |
| Function | Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome- surrounding area in a microtubule-independent and dependent manner, respectively. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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