癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Myocardin Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8IZQ8 |
| Other Accession | Q8IZQ8 |
| Reactivity | Human |
| Predicted | Rat, Pig, Mouse, Rabbit, Chicken, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 101997 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Myocardin |
| Epitope Specificity | 456-560/461-560/938 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 3 RPEL repeats.Contains 1 SAP domain. |
| SUBUNIT | Homodimer. Interacts with SRF, its association does not depend on specific DNA sequences for ternary complex formation. Interacts with MLLT7/FOXO4. Interacts (via C-terminal) with EP300 (via the CREB-binding domain). Interacts with HDAC4 and HDAC5 (By similarity). Interacts with MEF2C. |
| Post-translational modifications | Phosphorylation regulates negatively the intrinsic myocardin transcriptional activity. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Transcriptional factor that uses the canonical single or multiple CArG boxes DNA sequence. Binds CArG boxes only in the presence of serum response factor (SRF). Acts as a cofactor of SRF and modulates SRF-target genes. Regulates the expression of a set of cardiac and smooth muscle-specific genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. |
| Gene ID | 93649 |
|---|---|
| Other Names | MGBL; MYCD; BSAC2A; Srfcp; MYCD_HUMAN; MYOCD; MYCD_MOUSE; Basic SAP coiled-coil transcription activator 2; SRF cofactor protein; Bsac2; MYCD_RAT; myocardin |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1ug/test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MYOCD |
|---|---|
| Synonyms | MYCD |
| Function | Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). Positively regulates the transcription of genes involved in vascular smooth muscle contraction (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in the heart, aorta and bladder (PubMed:12640126, PubMed:20385216). Expressed in smooth muscle cell- containing tissues: stomach, small intestine, colon, lung, placenta and uterus (PubMed:12640126). Very faint expression in prostate and skeletal muscle (PubMed:12640126). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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