癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Syntaxin 1A + Syntaxin 1B Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P61266 |
| Other Accession | P61266 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33245 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Syntaxin 1A + Syntaxin 1B |
| Epitope Specificity | 201-288/288 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| SIMILARITY | Belongs to the syntaxin family. Contains 1 t-SNARE coiled-coil homology domain. |
| SUBUNIT | Interacts with OTOF. Interacts with SYT6 and SYT8; the interaction is Ca(2+)-dependent. |
| Post-translational modifications | Phosphorylated by CK2. |
| DISEASE | Generalized epilepsy with febrile seizures plus 9 (GEFSP9) [MIM:616172]: An autosomal dominant neurologic disorder characterized by febrile and/or afebrile seizures manifesting in early childhood. Seizure are variable and include generalized tonic-clonic, atonic, myoclonic, complex partial, and absence types. Most patients have remission of seizures later in childhood with no residual neurologic deficits. Rarely, patients may show mild developmental delay or mild intellectual disabilities. {ECO:0000269|PubMed:25362483}. Note=The disease is caused by mutations affecting the gene represented in this entry. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene belongs to a family of proteins thought to play a role in the exocytosis of synaptic vesicles. Vesicle exocytosis releases vesicular contents and is important to various cellular functions. For instance, the secretion of transmitters from neurons plays an important role in synaptic transmission. After exocytosis, the membrane and proteins from the vesicle are retrieved from the plasma membrane through the process of endocytosis. Mutations in this gene have been identified as one cause of fever-associated epilepsy syndromes. A possible link between this gene and Parkinson's disease has also been suggested. [provided by RefSeq, Jan 2015]. |
| Gene ID | 112755 |
|---|---|
| Other Names | GEFSP9; STX1B1; STX1B2; HPC-1; P35-1; STX1; SYN1A; Stx1bl; Syn1b; Stx2; STX1B_BOVIN; STX1B; Synaptocanalin I; Syntaxin-1B2; STX1B_HUMAN; Syntaxin-1B1; STX1B_MOUSE; STX1B_RAT; P35B; STX1B_SHEEP; syntaxin 1B; syntaxin 1B1; syntaxin 1B2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | STX1B |
|---|---|
| Synonyms | STX1B1, STX1B2 |
| Function | Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). |
| Cellular Location | [Isoform 1]: Membrane; Single-pass type IV membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97874
