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SH3GL2/Endophilin A1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q99962 |
| Other Accession | Q99962 |
| Reactivity | Rat, Mouse |
| Predicted | Cat, Human, Rabbit, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 39962 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SH3GL2/Endophilin 1 |
| Epitope Specificity | 201-300/352 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the endophilin family. Contains 1 BAR domain. Contains 1 SH3 domain. |
| SUBUNIT | Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Gene ID | 6456 |
|---|---|
| Other Names | CNSA2; EEN-B1; SH3D2A; SH3P4; 9530001L19Rik; B930049H17Rik; EEN1; SH3PA; SH3G2_HUMAN; SH3GL2; Endophilin-1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3G2_MOUSE; SH3G2_RAT; SH3 domain containing GRB2 like 2, endophilin A1; SH3 domain containing GRB2 like 2; endophilin-A1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SH3GL2 (HGNC:10831) |
|---|---|
| Synonyms | CNSA2, SH3D2A |
| Function | Implicated in endocytosis. Involved ultrafast endocytosis, by mediating, in a first step, neck formation and in a second step, aids in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O35179}. Membrane {ECO:0000250|UniProtKB:O35179}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35179}. Early endosome {ECO:0000250|UniProtKB:Q62420}. Presynapse {ECO:0000250|UniProtKB:O35179} |
| Tissue Location | Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97878
