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DNAJB9 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9UBS3 |
| Other Accession | Q9UBS3 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Chimpanzee, Human, Rabbit, Chicken, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25518 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DNAJB9 |
| Epitope Specificity | 24-120/223 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 J domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis. [provided by RefSeq, Dec 2010] |
| Gene ID | 4189 |
|---|---|
| Other Names | ERdj4; MDG-1; MDG1; MST049; MSTP049; CK820_G0011897; mDj7; DNJB9_HUMAN; DNAJB9; Endoplasmic reticulum DNA J domain-containing protein 4 (ER-resident protein ERdj4 | ERdj4); Microvascular endothelial differentiation gene 1 protein (Mdg-1); DNJB9_MOUSE; DNJB9_RAT; DnaJ heat shock protein family (Hsp40) member B9; DnaJ (Hsp40) homolog, subfamily B, member 9 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DNAJB9 |
|---|---|
| Synonyms | MDG1 {ECO:0000303|Ref.1} |
| Function | Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B- cell progenitors and normal antibody production (By similarity). |
| Cellular Location | Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q9QYI6} |
| Tissue Location | Widely expressed. Expressed at highest level in the liver, placenta and kidney (PubMed:11836248) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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