癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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DNAJC2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q99543 |
| Other Accession | Q99543 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 71996 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DNAJC2 |
| Epitope Specificity | 521-621/621 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 J domain. Contains 2 SANT domains. |
| Post-translational modifications | Phosphorylated in M (mitotic) phase. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008] |
| Gene ID | 27000 |
|---|---|
| Other Names | MPHOSPH11; MPP11; ZRF1; ZUO1; MIDA1; Zrf2; DNJC2_BOVIN; DNAJC2; Zuotin-related factor 1; DNJC2_HUMAN; M-phase phosphoprotein 11; DNJC2_MOUSE; Mouse Id associate 1 (MIDA1); DNJC2_RAT; Gliosarcoma-related antigen MIDA1; DnaJ heat shock protein family (Hsp40) member C2; zuotin related factor 1; DnaJ (Hsp40) homolog, subfamily C, member 2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DNAJC2 |
|---|---|
| Synonyms | MPHOSPH11, MPP11, ZRF1 |
| Function | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. |
| Cellular Location | Nucleus. Cytoplasm, cytosol |
| Tissue Location | Widely expressed.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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