癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CCDC46 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8N8E3 |
| Other Accession | Q8N8E3 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 112749 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CCDC46 |
| Epitope Specificity | 751-850/955 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a protein with filament, myosin tail and ATPase domains. Orthologs of this gene exist in mouse, rat and chimp. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. |
| Gene ID | 201134 |
|---|---|
| Other Names | CCDC46; MACOCO; SPGF44; 1700001M19Rik; 1700029K01Rik; 8430407H02Rik; RGD1564168; CE112_HUMAN; CEP112; Coiled-coil domain-containing protein 46; CE112_MOUSE; centrosomal protein 112; coiled-coil domain containing 46; centrosomal protein 112kDa |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CEP112 |
|---|---|
| Synonyms | CCDC46 |
| Function | Recruits mRNAs essential for sperm development, such as CFAP61 and FSIP2 mRNAs, into phase-separated condensates, thereby regulating their translation through a mechanism of liquid-liquid phase separation. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In spermatogonia and early spermatocytes, CEP112 has diffuse localization in both the cytoplasm and nucleus. As cells progress to the round spermatid stage, it begins to concentrate in distinct cytoplasmic foci. In elongating spermatids, these foci become more pronounced and localized primarily to the cytoplasm, often in close proximity to the developing acrosome and manchette. In mature spermatozoa, is localized to the neck region, atypical centrioles and the base of the axoneme |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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