癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Cyclin B3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8WWL7 |
| Other Accession | Q8WWL7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 157916 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Cyclin B3 |
| Epitope Specificity | 1117-1200/1395 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the cyclin family. Cyclin AB subfamily. |
| SUBUNIT | Interacts with CDK2 kinase. |
| Post-translational modifications | Ubiquitinated (Probable). Ubiquitination leads to itsdegradation during anaphase entry, after degradation of CCNB1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene belongs to the highlyconserved cyclin family, whose members are characterized by adramatic periodicity in protein abundance through the cell cycle.Cyclins function as positive regulators of cyclin-dependent kinases(CDKs), and thereby play an essential role in the control of thecell cycle. Different cyclins exhibit distinct expression anddegradation patterns, which contribute to the temporal coordinationof each mitotic event. Studies of similar genes in chicken anddrosophila suggest that this cyclin may associate with CDC2 andCDK2 kinases, and may be required for proper spindle reorganizationand restoration of the interphase nucleus. Alternatively splicedtranscript variants encoding different isoforms have been describedfor this gene. |
| Gene ID | 85417 |
|---|---|
| Other Names | CCNB3_HUMAN; CCNB3; CYCB3; cyclin B3 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=3ug/test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CCNB3 |
|---|---|
| Synonyms | CYCB3 |
| Function | Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I. |
| Cellular Location | Nucleus. |
| Tissue Location | Testis specific. In testis, it is expressed in developing germ cells, but not in Leydig cells. Weakly or not expressed in other tissues. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97903
