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ADCY2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q08462 |
| Other Accession | Q08462 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 123603 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ADCY2 |
| Epitope Specificity | 901-1091/1091 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains. |
| SUBUNIT | Interacts with RAF1. |
| Post-translational modifications | Phosphorylated by RAF1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ADCY2 is a membrane-bound, calmodulin-insensitive adenylyl cyclase. |
| Gene ID | 108 |
|---|---|
| Other Names | AC2; HBAC2; mKIAA1060; ADCY2_HUMAN; ADCY2; ATP pyrophosphate-lyase 2; Adenylate cyclase type II; Adenylyl cyclase 2; 4.6.1.1; KIAA1060; ADCY2_MOUSE; ADCY2_RAT; Adenylyl cyclase 2 (AC2); adenylate cyclase 2; adenylate cyclase 2 (brain) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ADCY2 |
|---|---|
| Synonyms | KIAA1060 |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). |
| Cellular Location | Membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm |
| Tissue Location | Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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