癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ADCY2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q08462 |
| Other Accession | Q08462 |
| Reactivity | Rat, Mouse |
| Predicted | Pig, Human, Rabbit, Chicken, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 123603 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ADCY2 |
| Epitope Specificity | 901-1091/1091 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains. |
| SUBUNIT | Interacts with RAF1. |
| Post-translational modifications | Phosphorylated by RAF1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ADCY2 is a membrane-bound, calmodulin-insensitive adenylyl cyclase. |
| Gene ID | 108 |
|---|---|
| Other Names | AC2; HBAC2; mKIAA1060; ADCY2_HUMAN; ADCY2; ATP pyrophosphate-lyase 2; Adenylate cyclase type II; Adenylyl cyclase 2; 4.6.1.1; KIAA1060; ADCY2_MOUSE; ADCY2_RAT; Adenylyl cyclase 2 (AC2); adenylate cyclase 2; adenylate cyclase 2 (brain) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ADCY2 |
|---|---|
| Synonyms | KIAA1060 |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). |
| Cellular Location | Membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm |
| Tissue Location | Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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