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srGAP3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | O43295 |
| Other Accession | O43295 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 124504 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human srGAP3 |
| Epitope Specificity | 201-300/1099 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBUNIT | Interacts with WASF1. Probably interacts with ROBO1. Interacts with FASLG. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | srGAP3 (SLIT ROBO Rho GTPase-activating protein 3) is a GTPase activating protein (GAP) for the small G protein Rac. It has a putative role in attenuating Rac1 signalling in neurons. srGAP3 is thought to act downstream of the Slit-Robo pathway, which regulates neuronal migration and axonal branching, and play an important role in axonal regeneration after axotomy. It also plays a putative role in severe mental retardation. |
| Gene ID | 9901 |
|---|---|
| Other Names | ARHGAP14; MEGAP; SRGAP2; WRP; D130026O08Rik; Gbi; mKIAA0411; RGD1563152; SRGP3_HUMAN; SRGAP3; Mental disorder-associated GAP; Rho GTPase-activating protein 14; WAVE-associated Rac GTPase-activating protein (WRP); KIAA0411; KIAA1156; SRGP3_MOUSE; SLIT-ROBO Rho GTPase activating protein 3; SLIT-ROBO Rho GTPase activating protein 2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SRGAP3 |
|---|---|
| Synonyms | ARHGAP14, KIAA0411, KIAA1156, MEGAP, SRG |
| Function | GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons. |
| Tissue Location | Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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