癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DOS Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8N350 |
| Other Accession | Q8N350 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 73929 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CBARP |
| Epitope Specificity | 501-600/705 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc Alpha receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes have been linked to chromosome 19. Translocations with chromosome 19 and chromosome 14 can be seen in some lymphoproliferative disorders and typically involve the proto-oncogene BCL3. The C19orf26 gene product has been provisionally designated C19orf26 pending further characterization. |
| Gene ID | 255057 |
|---|---|
| Other Names | BARP; C19orf26; DOS; CBARP_HUMAN; CBARP; CACN subunit beta associated regulatory protein; chromosome 19 open reading frame 26; calcium channel, voltage-dependent, beta subunit associated regulatory protein; CACN beta subunit associated regulatory protein; downstream of STK11; VGCC beta-anchoring and -regulatory protein |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CBARP (HGNC:28617) |
|---|---|
| Function | Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q66L44}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q66L44}. Cell membrane {ECO:0000250|UniProtKB:Q66L44}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q66L44}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q66L44} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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