癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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GSTM2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P28161 |
| Other Accession | P28161 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25745 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GSTM2 |
| Epitope Specificity | 121-218/218 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the GST superfamily. Mu family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008] |
| Gene ID | 2946 |
|---|---|
| Other Names | GST4; GSTM; GSTM2-2; GTHMUS; Gstb-2; Gstb2; GSTA4; GSTM2_HUMAN; GSTM2; GST class-mu 2; 2.5.1.18; GSTM2_MOUSE; GST 5-5; Glutathione S-transferase pmGT2; GSTM2_RAT; GST 4-4; Glutathione S-transferase Yb-2 (GST Yb2); glutathione S-transferase mu 2; glutathione S-transferase M2 (muscle); glutathione S-transferase mu 2 (muscle) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GSTM2 (HGNC:4634) |
|---|---|
| Synonyms | GST4 |
| Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Muscle. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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