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MATH5 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8N100 |
| Other Accession | Q8N100 |
| Reactivity | Mouse |
| Predicted | Rat, Human, Rabbit, Chicken, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 16871 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MAT2A |
| Epitope Specificity | 31-120/152 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 basic helix-loop-helix (bHLH) domain. |
| Post-translational modifications | The alpha' subunit is a post-translationally modified version of MAT2A. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment. [provided by RefSeq, Dec 2011] |
| Gene ID | 220202 |
|---|---|
| Other Names | Math5; NCRNA; PHPVAR; RNANC; bHLHa13; ATOH7_HUMAN; ATOH7; Atonal bHLH transcription factor 7; Class A basic helix-loop-helix protein 13 (bHLHa13); Protein atonal homolog 7; ATH5; ATOH7_MOUSE; Helix-loop-helix protein mATH-5 (mATH5); atonal homolog 7 (Drosophila); atonal homolog bHLH transcription factor 7 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ATOH7 (HGNC:13907) |
|---|---|
| Synonyms | ATH5, BHLHA13 |
| Function | Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (PubMed:31696227). Dimerization with TCF3 isoform E47 may be required in certain situations (PubMed:31696227). Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes (By similarity). Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract (By similarity). Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription (By similarity). Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity). |
| Cellular Location | Nucleus. Perikaryon {ECO:0000250|UniProtKB:Q9Z2E5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2E5} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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