癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LMBR1L Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q6UX01 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55209 Da |
| Antigen Region | 462-489 aa |
| Gene ID | 55716 |
|---|---|
| Other Names | Protein LMBR1L, Limb region 1 protein homolog-like, Lipocalin-1-interacting membrane receptor, Lipocalin-interacting membrane receptor, LMBR1L, KIAA1174, LIMR |
| Target/Specificity | This LMBR1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 462-489 amino acids from the C-terminal region of human LMBR1L. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LMBR1L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LMBR1L |
|---|---|
| Synonyms | KIAA1174, LIMR |
| Function | Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta- catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in testis, pituitary gland, adrenal gland, trachea, placenta, thymus, cerebellum, stomach, mammary gland, spinal cord. A weaker expression is detected in colon, pancreas, and prostate. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Rutsch, F., et al. Nat. Genet. 41(2):234-239(2009)
Fluckinger, M., et al. Biochim. Biophys. Acta 1778(1):342-347(2008)
Zhang, Z., et al. Gene 369, 66-71 (2006) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Wojnar, P., et al. J. Biol. Chem. 278(18):16209-16215(2003)
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¥ 1,250.00
Cat# AP9794b
