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GABRQ Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UN88 |
| Other Accession | Q9UN88 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 71988 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GABRQ/GABA A Receptor theta |
| Epitope Specificity | 211-320/632 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily. |
| SUBUNIT | Generally pentameric. This subunit coassembles with alpha-2, beta-1 and gamma-1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009] |
| Gene ID | 55879 |
|---|---|
| Other Names | THETA; GBRT_HUMAN; GABRQ; GABA(A) receptor subunit theta (GABAAR subunit theta); A2AEH2_MOUSE; Q0VEX8_MOUSE; GABA(A) receptor subunit theta; GBRT_MOUSE; Q91ZM7_RAT; gamma-aminobutyric acid type A receptor subunit theta; gamma-aminobutyric acid (GABA) receptor, theta; GABA(A) receptor, theta |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GABRQ (HGNC:14454) |
|---|---|
| Function | Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217). GABA- gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:10449790, PubMed:16412217). |
| Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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