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Kir2.2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q14500 |
| Other Accession | Q14500 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 49001 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Kir2.2 |
| Epitope Specificity | 351-433/433 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. |
| Gene ID | 3768 |
|---|---|
| Other Names | IRK; Kir2.2; IRK-2; IRK2; KCNJN1; hIRK; hIRK1; hkir2.2x; kcnj12x; MB-IRK2; Kir2.1; KCJ12_BOVIN; KCNJ12; Potassium channel, inwardly rectifying subfamily J member 12; KCJ12_HUMAN; Inward rectifier K(+) channel Kir2.2 (IRK-2); Inward rectifier K(+) channel Kir2.2v; KCJ12_MOUSE; KCJ12_RAT; potassium inwardly rectifying channel subfamily J member 12; potassium inwardly-rectifying channel, subfamily J, inhibitor 1; potassium inwardly-rectifying channel, subfamily J, member 12 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KCNJ12 |
|---|---|
| Synonyms | IRK2, KCNJN1 |
| Function | Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. |
| Cellular Location | Membrane; Multi-pass membrane protein. Cell membrane Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:P52188} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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