癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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Lano/LRRC1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9BTT6 |
| Other Accession | Q9BTT6 |
| Predicted | Rat, Pig, Human, Mouse, Rabbit, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59242 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Lano/LRRC1 |
| Epitope Specificity | 261-360/524 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 17 LRR (leucine-rich) repeats. |
| SUBUNIT | Interacts with DLG1 and DLG4. May form a complex with DLG1 and ERBB2IP, where interaction between LRRC1 and ERBB2IP is indirect. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The primary function of these motifs is to provide a versatile structural framework to mediate the formation of protein-protein interactions. LRRs are present in a variety of proteins with diverse structure and function, including innate immunity and nervous system development. LRRC1 (leucine-rich repeat-containing protein 1), also known as LANO adapter protein or LAP and no PDZ protein, is a 524 amino acid protein that contains 17 LRR repeats. Localized to the cytoplasm and the membrane, LRRC1 is expressed strongly in placenta and testis, with lower levels found in heart, kidney, thyroid, lung, prostate, colon and trachea. LRRC1 interacts with PSD-95 and SAP 97, and may form a complex with SAP 97 and ERBIN. LRRC1 is expressed as two isoforms produced by alternative splicing events. |
| Gene ID | 55227 |
|---|---|
| Other Names | LANO; dJ523E19.1; LRRC1_HUMAN; LRRC1; LANO adapter protein; LAP and no PDZ protein; leucine rich repeat containing 1; leucine-rich repeat-containing 1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LRRC1 |
|---|---|
| Synonyms | LANO |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized at the basolateral side of epithelial cells |
| Tissue Location | Expressed strongly in testis and placenta, followed by heart, lung, kidney, thyroid, trachea, colon, prostate and pancreas |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97986
