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ADAMTS6 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9UKP5 |
| Other Accession | Q9UKP5 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 125273 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ADAMTS6 |
| Epitope Specificity | 231-330/1117 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| SIMILARITY | Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Contains 1 PLAC domain. Contains 5 TSP type-1 domains. |
| Post-translational modifications | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). |
| DISEASE | Isoform 1 and isoform 2 expressions are up-regulated by TNF in retinal pigment epithelial cells. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008] |
| Gene ID | 11174 |
|---|---|
| Other Names | ADAM-TS 6; ADAM-TS6; ADAMTS-6; A930019D11Rik; b2b1879.1Clo; b2b2029Clo; b2b2182Clo; b2b2187.1Clo; b2b2228Clo; ATS6_HUMAN; ADAMTS6; 3.4.24.-; ADAM metallopeptidase with thrombospondin type 1 motif 6; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6; a disintegrin and metalloproteinase with thrombospondin motifs 6 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ADAMTS6 |
|---|---|
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Expressed at low levels in placenta and barely detectable in a number of other tissues |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP97992
