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KRT84 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9NSB2 |
| Other Accession | Q9NSB2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 64842 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KRT84 |
| Epitope Specificity | 401-500/600 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the intermediate filament family. |
| SUBUNIT | Heterotetramer of two type I and two type II keratins. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins. [provided by RefSeq, Jul 2008] |
| Gene ID | 3890 |
|---|---|
| Other Names | HB4; KRTHB4; HRb-1; Krt2-16; Krt2-3; Kb24; KRT84_HUMAN; KRT84; Keratin-84 (K84); Type II hair keratin Hb4; Type-II keratin Kb24; KRT84_MOUSE; 65 kDa type II keratin; keratin 84; keratin, hair, basic, 4; keratin 84, type II; hard keratin type II 4 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KRT84 (HGNC:6461) |
|---|---|
| Synonyms | KRTHB4 |
| Function | Structural component of intermediate filaments in keratinizing epithelia (PubMed:11445569). As a type II hair keratin, forms obligate heterodimers with type I keratins to assemble keratin intermediate filaments (By similarity). Expressed predominantly in the posterior compartment of the filiform papillae of the tongue, where it contributes to the structural integrity and mechanical resilience of specialized keratinized epithelial cells (Probable). |
| Tissue Location | Expressed in non-hair stratified epithelia, including the posterior compartment of the tongue filiform papillae (PubMed:11445569). Expressed in the hair follicles |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP98037
