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Synaptotagmin 5 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O00445 |
| Other Accession | O00445 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42900 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Synaptotagmin 5 |
| Epitope Specificity | 201-300/386 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the synaptotagmin family.Contains 2 C2 domains. |
| SUBUNIT | Homodimer. Can also form heterodimers with SYT6. Interacts with both alpha- and beta-tubulin (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]. |
| Gene ID | 6861 |
|---|---|
| Other Names | SytV; SYT5_HUMAN; SYT5; Synaptotagmin V (SytV); SYT5_MOUSE; Synaptotagmin IX; Syt9; synaptotagmin 5; synaptotagmin V |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SYT5 |
|---|---|
| Function | May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Note=In mast cells, localizes to the endocytic recycling compartment. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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