Ctip2 Rabbit pAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P, IHC-F, IF
Primary Accession	Q9C0K0
Other Accession	Q9C0K0
Host	Rabbit
Clonality	Polyclonal
Calculated MW	95519 Da
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human Ctip2
Epitope Specificity	331-4630/894
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SIMILARITY	Contains 6 C2H2-type zinc fingers.
SUBUNIT	Interacts with TFCOUP1, SIRT1, ARP1 and EAR2
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions	This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Additional Information
Gene ID	64919
Other Names	ATL1; ATL1-alpha; ATL1-beta; ATL1-delta; ATL1-gamma; CTIP-2; CTIP2; IDDFSTA; IMD49; RIT1; SMARCM2; ZNF856B; hRIT1-alpha; 9130430L19Rik; B630002E05Rik; BCL-11B; BC11B_HUMAN; BCL11B; B-cell CLL/lymphoma 11B; COUP-TF-interacting protein 2; Radiation-induced tumor suppressor gene 1 protein (hRit1); BC11B_MOUSE; Radiation-induced tumor suppressor gene 1 protein (mRit1); BCL11 transcription factor B; B-cell CLL/lymphoma 11B (zinc finger protein); B cell CLL/lymphoma 11B; BCL11B, BAF complex component; BAF chromatin remodeling complex subunit BCL11B
Dilution	IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	BCL11B
Synonyms	CTIP2, RIT1
Function	Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity).
Cellular Location	Nucleus.
Tissue Location	Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma