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为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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Nogo B receptor Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q96E22 |
| Other Accession | Q96E22 |
| Predicted | Rat, Pig, Human, Mouse, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33224 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NGBR/Nogo B receptor |
| Epitope Specificity | 167-210/293 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the UPP synthase family. |
| SUBUNIT | Interacts with DHDDS, promoting its isoprenyltransferase activity. Interacts with NPC2. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NgBR (Nogo-B receptor), also known as nuclear undecaprenyl pyrophosphate synthase 1 homolog, is a 293 amino acid single-pass type I membrane protein that acts as a specific receptor for the amino-terminus of Nogo-B. Through this interaction, NgBR is involved in the regulation of vascular remodeling and angiogenesis. NgBR also enhances Niemann-Pick type C2 protein (NPC2) stabilization. Knockdown of NgBR mRNA leads to decreased NPC2 levels, which results in the hallmarks of NPC2 mutation: increased intracellular cholesterol accumulation and a loss of sterol sensing. |
| Gene ID | 116150 |
|---|---|
| Other Names | C6orf68; CDG1AA; MGC:7199; MRD55; NgBR; TANGO14; 1600027K07Rik; D10Ertd438e; RGD1307879; NGBR_HUMAN; NUS1; Cis-prenyltransferase subunit NgBR; Nogo-B receptor (NgBR); Nuclear undecaprenyl pyrophosphate synthase 1 homolog; 2.5.1.87; NGBR_MOUSE; NUS1 dehydrodolichyl diphosphate synthase subunit; chromosome 6 open reading frame 68; nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Nogo-B receptor; transport and golgi organization 14 homolog (Drosophila) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NUS1 {ECO:0000303|PubMed:28842490, ECO:0000312|HGNC:HGNC:21042} |
|---|---|
| Function | With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490, PubMed:32817466, PubMed:33077723). Synthesizes long- chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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