癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Nephronectin Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q6UXI9 |
| Other Accession | Q6UXI9 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61907 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Nephronectin |
| Epitope Specificity | 501-565/565 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the nephronectin family. Contains 5 EGF-like domains. Contains 1 MAM domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Nephronectin is a 565 amino acid member of the nephronectin family that contains five EGF-like domains and an Arg-Gly-Asp (RGD) cell binding motif, as well as a meprin, A5 protein and receptor protein-tyrosine phosphatase µ (MAM) domain. Expressed in kidney, thyroid and parathyroid glands, developing bone, tooth germ, skeletal and smooth muscle, brain and skin, POEM is involved in the development and function of bone, muscle and kidney tissue. The most established function of POEM is as a ligand to the receptor Integrin å8/∫1. Highly expressed in the nephritic cord, Integrin å8/∫1 plays a critical role in kidney morphogenesis and development. The POEM-Integrin å8∫1 complex regulates the expression of GDNF, another protein that affects kidney development, specifically by regulating the growth of the uretic bud. There are two named isoforms of POEM, both of which form homodimers or homotrimers. |
| Gene ID | 255743 |
|---|---|
| Other Names | EGFL6L; POEM; 1110009H02Rik; Nctn; NPNT_HUMAN; NPNT; Preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like; NPNT_MOUSE; Neph1; nephronectin |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NPNT |
|---|---|
| Synonyms | EGFL6L, POEM |
| Function | Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity). |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Note=Trapped on the cell surface or in the extracellular matrix. |
| Tissue Location | Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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