癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
L2HGDH Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9H9P8 |
| Other Accession | Q9H9P8 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50316 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human L2HGDH |
| Epitope Specificity | 201-300/463 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the L2HGDH family. |
| DISEASE | Defects in L2HGDH are the cause of L-2-hydroxyglutaric aciduria (L2HGA) [MIM:236792]. L2HGA is a rare autosomal recessive disorder clinically characterized by mild psychomotor delay in the first years of life, followed by progressive cerebellar ataxia, dysarthria and moderate to severe mental retardation. Diagnosis is based on the presence of an excess of L-2-hydroxyglutaric acid in urine, blood and cerebrospinal fluid. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe mental retardation. [provided by RefSeq, Jul 2008] |
| Gene ID | 79944 |
|---|---|
| Other Names | C14orf160; L2HGA; RGD1306250; L2HDH_BOVIN; L2HGDH; Duranin; 1.1.99.2; L2HDH_HUMAN; L2HDH_MOUSE; L2HDH_PONAB; L-2-hydroxyglutarate dehydrogenase; chromosome 14 open reading frame 160; 2-hydroxyglutarate dehydrogenase |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | L2HGDH (HGNC:20499) |
|---|---|
| Function | Catalyzes the oxidation of L-2-hydroxyglutarate to 2- oxoglutarate (alpha-ketoglutarate). |
| Cellular Location | Mitochondrion. |
| Tissue Location | Widely expressed. Highly expressed in brain, testis and muscle. Expressed to a lower extent in lymphocytes, fibroblasts, keratinocytes, placenta, bladder, small intestine, liver and bone marrow. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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