癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MECR Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9BV79 |
| Other Accession | Q9BV79 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40462 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MECR |
| Epitope Specificity | 131-230/373 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Mecr is a 373 amino acid mitochondrial protein that may play a role in fatty acid synthesis. Existing as two alternatively spliced isoforms, Mecr is highly expressed in cardiac and skeletal muscle, with lower levels found in pancreas, kidney, placenta and liver. Mecr forms a homodimer and belongs to the zinc-containing alcohol dehydrogenase family and quinone oxidoreductase subfamily. Mecr reduces trans-2-enoyl-CoA to acyl-CoA in an NADPH-dependent manner and is encoded by a gene that maps to human chromosome 1p35.3. Human chromosome 1 spans 260 million base pairs, contains over 3,000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. |
| Gene ID | 51102 |
|---|---|
| Other Names | CGI-63; DYTOABG; ETR1; FASN2B; NRBF1; OPA16; NRBF-1; MECR_HUMAN; MECR; 2-enoyl thioester reductase; Nuclear receptor-binding factor 1 (HsNrbf-1 | NRBF-1); 1.3.1.104; NBRF1; MECR_MOUSE; Nuclear receptor-binding factor 1 (NRBF-1); MECR_RAT; mitochondrial trans-2-enoyl-CoA reductase; nuclear receptor binding factor 1; mitochondrial 2-enoyl thioester reductase |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MECR |
|---|---|
| Synonyms | NBRF1 |
| Function | Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (PubMed:12654921, PubMed:18479707, PubMed:27817865). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (By similarity). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism (PubMed:37653044). Required for proper morphology and bioenergetic functions of mitochondria (PubMed:37653044). Required for maintenance of neurons (By similarity). |
| Cellular Location | [Isoform 1]: Mitochondrion |
| Tissue Location | Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas Weakly or not expressed in lung. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98126
