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ASH1L Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9NR48 |
| Other Accession | Q9NR48 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Human, Rabbit, Chicken, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 332790 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ASH1L |
| Epitope Specificity | 1951-2100/2969 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the histone-lysine methyltransferase family. SET2 subfamily. Contains 3 A.T hook DNA-binding domains.Contains 1 AWS domain. Contains 1 BAH domain. Contains 1 bromo domain. Contains 1 PHD-type zinc finger. Contains 1 post-SET domain. Contains 1 SET domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ASH1L is a 2,969 amino acid protein encoded by the human gene ASH1L. ASH1L belongs to the histone-lysine methyltransferase family (SET2 subfamily) and contains three AT hook DNA-binding domains, one AWS domain, one BAH domain, one bromodomain, one PHD-type zinc finger, one post-SET domain and one SET domain. It is a widely expressed nuclear protein with highest expression found in brain, heart and kidney. ASH1L is a histone methyltransferase and is believed to methylate 'Lys-4' of Histone H3, which is a specific tag for epigenetic transcriptional activation. |
| Gene ID | 55870 |
|---|---|
| Other Names | ASH1; ASH1L1; KMT2H; MRD52; ASH1L_HUMAN; ASH1L; ASH1-like protein (huASH1); Absent small and homeotic disks protein 1 homolog; Lysine N-methyltransferase 2H; 2.1.1.359; 2.1.1.367; KIAA1420; ASH1 like histone lysine methyltransferase; ash1 (absent, small, or homeotic)-like (Drosophila) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ASH1L |
|---|---|
| Synonyms | KIAA1420, KMT2H |
| Function | Histone methyltransferase specifically trimethylating 'Lys- 36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). |
| Cellular Location | Nucleus. Cell junction, tight junction. Chromosome. Note=The relevance of tight junction localization is however unclear. |
| Tissue Location | Widely expressed, with highest level in brain, heart and kidney. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98137
