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phospho-ACACA (Ser79) Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q5SWU9 |
| Other Accession | Q5SWU9 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 265257 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthesised phosphopeptide derived from mouse Acetyl Coenzyme A Carboxylase around the phosphorylation site of Ser79 |
| Epitope Specificity | SM(p-S)GL |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 ATP-grasp domain.Contains 1 biotin carboxylation domain.Contains 1 biotinyl-binding domain.Contains 1 carboxyltransferase domain. |
| SUBUNIT | Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity. |
| Post-translational modifications | Phosphorylation on Ser-1263 is required for interaction with BRCA1. |
| DISEASE | Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
| Gene ID | 107476 |
|---|---|
| Other Names | ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta; HACC275; A530025K05Rik; Acac; Acc1; Gm738; ACACA_HUMAN; ACACA; Acetyl-Coenzyme A carboxylase alpha (ACC-alpha); 6.4.1.2; ACCA; ACACA_MOUSE; ACC-alpha; Acetyl-CoA carboxylase 265; ACACA_RAT; acetyl-CoA carboxylase alpha; acetyl-Coenzyme A carboxylase alpha; acetyl-CoA carboxylase 1; ACACA (phospho-S79); p-ACACA; phospho-ACACA; ACACA (phospho-Ser79) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Acaca {ECO:0000312|MGI:MGI:108451} |
|---|---|
| Function | Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656). |
| Cellular Location | Cytoplasm, cytosol |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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