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CACNB3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P54284 |
| Other Accession | P54284 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 54532 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CACNB3 |
| Epitope Specificity | 101-200/484 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the calcium channel beta subunit family. Contains 1 SH3 domain. |
| SUBUNIT | The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with CACNA2D4. Interacts with FASLG. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an Alpha1 subunit, a Beta subunit, a Beta subunit and an Alpha2 Gamma subunit. The Beta subunit is encoded by four genes, designated Beta1-Beta4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the Beta subunit. L-type Ca++ CP Beta3, also known as CACNB3 (Calcium channel voltage-dependent subunit beta 3), CACNLB3 or CAB3, is a 484 amino acid protein that contains one SH3 domain and is expressed in ovary, brain and smooth muscle. Functioning as one of the four components of the Beta subunit, L-type Ca++ CP Beta 3 increases the peak calcium current in voltage-dependent calcium channels, thereby shifting the voltage dependencies of activation and inactivation and controlling G protein inhibition and Beta membrane targeting. Two isoforms of L-type Ca++ CP Beta3 exist due to alternative splicing events. |
| Gene ID | 784 |
|---|---|
| Other Names | CAB3; CACNLB3; Beta3; Ca(v)beta3; Cchb3; CACH3B; CACB3_HUMAN; CACNB3; Calcium channel voltage-dependent subunit beta 3; CACB3_MOUSE; Calcium channel voltage-dependent subunit beta 3 (CCHB3); CACB3_RAT; calcium voltage-gated channel auxiliary subunit beta 3; calcium channel, voltage-dependent, beta 3 subunit |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CACNB3 |
|---|---|
| Synonyms | CACNLB3 {ECO:0000303|PubMed:7557998} |
| Function | Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed mostly in brain, colon and ovary. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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