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PGAM1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P18669 |
| Other Accession | P18669 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28804 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human PGAM1 |
| Epitope Specificity | 101-200/254 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. |
| SUBUNIT | Homodimer. |
| Post-translational modifications | Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | PGAM1 belongs to the phosphoglycerate mutase family, BPG-dependent PGAM subfamily. It is involved in the interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. |
| Gene ID | 5223 |
|---|---|
| Other Names | HEL-S-35; PGAM-B; PGAMA; 2310050F24Rik; Pgam-1; Pgmut; PGAM1_HUMAN; PGAM1; BPG-dependent PGAM 1; Phosphoglycerate mutase isozyme B (PGAM-B); 5.4.2.11; 5.4.2.4; PGAM1_MOUSE; PGAM1_RAT; phosphoglycerate mutase 1; phosphoglycerate mutase 1 (brain); Phosphoglycerate mutase A, nonmuscle form |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PGAM1 (HGNC:8888) |
|---|---|
| Synonyms | PGAMA |
| Function | Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate, a crucial step in glycolysis, by using 2,3- bisphosphoglycerate (PubMed:23653202). Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho- glyceroyl phosphate (PubMed:23653202). |
| Tissue Location | Expressed in the liver and brain. Not found in the muscle. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98214
