癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GM2A Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P17900 |
| Other Accession | P17900 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 20838 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GM2A/SAP3 |
| Epitope Specificity | 131-193/193 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Post-translational modifications | The serines in positions 32 and 33 are absent in 80% of the sequenced protein. |
| DISEASE | Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]. |
| Gene ID | 2760 |
|---|---|
| Other Names | GM2-AP; GM2AP; SAP-3; SAP3_HUMAN; GM2A; Cerebroside sulfate activator protein; Sphingolipid activator protein 3 (SAP-3); SAP3_MOUSE; ganglioside GM2 activator; GM2 ganglioside activator protein; GM2 ganglioside activator; sphingolipid activator protein 3; GM2-activator protein |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GM2A (HGNC:4367) |
|---|---|
| Function | Lipid-binding and transfer protein essential for lysosomal degradation of ganglioside GM2. Extracts single GM2 molecules from intralysosomal luminal vesicle (ILV) membranes and presents them in soluble form to beta-hexosaminidase A (HEXA) for cleavage of N-acetyl- D-galactosamine and conversion to GM3 (PubMed:30988135, PubMed:8900233). Forms a stoichiometric GM2-GM2A complex that serves as the substrate for HEXA (PubMed:30988135, PubMed:8900233). Also stimulates the breakdown of glycolipid GA2 by HEXA (By similarity). Possesses dual function: membrane lipid mobilization/solubilization and lipid substrate presentation to hydrolases (PubMed:30988135). The large binding pocket can accommodate several single-chain phospholipids and fatty acids (By similarity). Exhibits some calcium-independent phospholipase activity (By similarity). Participates in cholesterol transfer (PubMed:17552909). |
| Cellular Location | Lysosome. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
