癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Multicilin Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | D6RGH6 |
| Other Accession | D6RGH6 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41720 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Multicilin |
| Epitope Specificity | 281-385/385 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the geminin family. |
| SUBUNIT | Homodimer. Interacts with GMNN; targets GMNN to the nucleus, prevents GMNN interaction with CDT1 and competes with IDAS homodimerization. |
| DISEASE | Probable target of the anaphase promoting complex/cyclosome (APC/C) which regulates its level in the cell during the mitotic cell cycle. Highly expressed during interphase and early mitosis. Expression decreases during anaphase to become undetectable during telophase and cytokinesis. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Transcription regulator required for multiciliate cell differentiation. Acts by promoting transcription of genes required for multiciliate cell formation. Probably acts in a multiprotein complex (By similarity). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. |
| Gene ID | 345643 |
|---|---|
| Other Names | CILD42; IDAS; MCI; MCIN; MCIN_HUMAN; MCIDAS; Multiciliate differentiation and DNA synthesis-associated cell cycle protein (McIdas protein); Protein Idas; multiciliate differentiation and DNA synthesis associated cell cycle protein; multiciliate cell differentiation 1; multicilin |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MCIDAS (HGNC:40050) |
|---|---|
| Synonyms | IDAS, MCI, MCIN |
| Function | Transcription regulator specifically required for multiciliate cell differentiation (PubMed:25048963). Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome- mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211). |
| Cellular Location | Nucleus. Note=Excluded from the nucleolus |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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