癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DAL1/EPB41L3 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9Y2J2 |
| Other Accession | Q9Y2J2 |
| Reactivity | Rat, Human, Mouse |
| Predicted | Pig, Rabbit, Chicken, Dog, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 120678 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DAL1/EPB41L3 |
| Epitope Specificity | 131-230/1087 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | ontains 1 FERM domain. |
| SUBUNIT | Interacts with CADM1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | EPB41L3 is an actin-binding protein originally identified as a molecule whose expression is down-regulated in lung adenocarcinoma. EPB41L3 is a member of the protein 4.1 superfamily, which encompasses structural proteins that play important roles in membrane processes via interactions with actin, spectrin, and the cytoplasmic domains of integral membrane proteins. The gene for EPB41L3 is thought to function as a tumor suppressor and localizes within chromosomal region 18p11.3, which is affected by loss of heterozygosity (LOH) in various adult tumors. |
| Gene ID | 23136 |
|---|---|
| Other Names | 4.1B; DAL-1; DAL1; DAL1P; Epb4.1l3; NBL3; Kiaa0987; E41L3_HUMAN; EPB41L3; Differentially expressed in adenocarcinoma of the lung protein 1 (DAL-1); Erythrocyte membrane protein band 4.1-like 3; E41L3_MOUSE; Differentially expressed in adenocarcinoma of the lung protein 1 (DAL-1 | DAL1P | mDAL-1); erythrocyte membrane protein band 4.1 like 3 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | EPB41L3 (HGNC:3380) |
|---|---|
| Function | Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm Note=Detected in the cytoplasm of actively dividing cells |
| Tissue Location | Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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