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MEX3C Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q5U5Q3 |
| Other Accession | Q5U5Q3 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 69366 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MEX3C |
| Epitope Specificity | 411-500/659 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 2 KH domains. Contains 1 RING-type zinc finger. |
| SUBUNIT | Interacts with USP7, which antagonizes the ability to degrade mRNA. |
| DISEASE | Note=Genetic variations in MEX3C may be associated with susceptibility to essential hypertension. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009] |
| Gene ID | 51320 |
|---|---|
| Other Names | BM-013; MEX-3C; RKHD2; RNF194; A130001D14Rik; MEX3C_HUMAN; MEX3C; RING finger and KH domain-containing protein 2; RING finger protein 194; RING-type E3 ubiquitin transferase MEX3C; 2.3.2.27; MEX3C_MOUSE; mex-3 RNA binding family member C; ring finger and KH domain containing 2; mex-3 homolog C (C. elegans) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MEX3C |
|---|---|
| Synonyms | RKHD2, RNF194 |
| Function | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. |
| Cellular Location | Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation |
| Tissue Location | Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells Week expression in the intestine. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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