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KCTD17 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8N5Z5 |
| Other Accession | Q8N5Z5 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34888 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KCTD17 |
| Epitope Specificity | 1-100/521 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 BTB (POZ) domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | KCTD16 (potassium channel tetramerisation domain containing 16), also known as BTB/POZ domain-containing protein KCTD16, is a 428 amino acid protein that contains one BTB (POZ) domain. An auxiliary subunit of GABAB R1 and GABAB R2, KCTD16 increases agonist potency and alters the G-protein signaling of the receptors by accelerating onset and promoting desensitization. |
| Gene ID | 79734 |
|---|---|
| Other Names | KCD17_HUMAN; KCTD17; potassium channel tetramerization domain containing 17; potassium channel tetramerisation domain containing 17 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KCTD17 (HGNC:25705) |
|---|---|
| Function | Substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down- regulation. Thereby, positively regulates ciliogenesis, playing a crucial role in the initial steps of axoneme extension (PubMed:25270598). May also play a role in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highly expressed in brain. Highest expression is observed in the putamen and the thalamus |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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