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NIS Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q92911 |
| Other Accession | Q92911 |
| Reactivity | Rat, Mouse |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 68666 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NIS |
| Epitope Specificity | 525-618/618 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. |
| DISEASE | Thyroid dyshormonogenesis 1 (TDH1) [MIM:274400]: A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Note=The disease is caused by mutations affecting the gene represented in this entry. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | catalyzes Na+/I- symporter activity plays a role in iodide transport and thyroid hormone generation.Human Sodium Iodide Symporter (hNIS) is responsible for iodide concentrating ability within thyroid follicular cells. It is a membrane bound glycoprotein with 13 membrane spanning domains and 14 extramembranous domains. It may represent an autoantigen in thyroid. |
| Gene ID | 6528 |
|---|---|
| Other Names | NIS; TDH1; SC5A5_HUMAN; SLC5A5; Na(+)/I(-) cotransporter; Natrium iodide transporter; Sodium-iodide symporter (Na(+)/I(-) symporter); Solute carrier family 5 member 5; SC5A5_RAT; solute carrier family 5 (sodium iodide symporter), member 5; solute carrier family 5 (sodium/iodide cotransporter), member 5; sodium iodide symporter |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC5A5 |
|---|---|
| Synonyms | NIS {ECO:0000303|PubMed:32084174, ECO:00 |
| Function | Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:20797386, PubMed:31310151, PubMed:32084174, PubMed:8806637, PubMed:9329364). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q63008}. Cytoplasm |
| Tissue Location | Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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