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MAPK4 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P31152 |
| Other Accession | P31152 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 65922 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MAPK4 |
| Epitope Specificity | 21-130/587 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain. |
| SUBUNIT | Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5. |
| Post-translational modifications | Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets. [provided by RefSeq, Jul 2008] |
| Gene ID | 5596 |
|---|---|
| Other Names | ERK-4; ERK4; PRKM4; p63-MAPK; p63MAPK; A330097D03Rik; Erk3; MK04_HUMAN; MAPK4; MAP kinase 4; MAPK 4; Extracellular signal-regulated kinase 4 (ERK-4); MAP kinase isoform p63 (p63-MAPK); 2.7.11.24; MK04_MOUSE; MK04_RAT; MNK2; mitogen-activated protein kinase 4 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,Flow-Cyt=2ug/Test |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MAPK4 |
|---|---|
| Synonyms | ERK4, PRKM4 |
| Function | Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Note=Translocates to the cytoplasm following interaction with MAPKAPK5 |
| Tissue Location | High expression in heart and brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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