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NPY1R Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P25929 |
| Other Accession | P25929 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44392 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NPY1R |
| Epitope Specificity | 221-270/384 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the G-protein coupled receptor 1 family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. There are two major subtypes of NPY (Y1 and Y2). The NPY Y1 receptors have been identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, breast, colon, ganglion, heart, and aortic smooth muscle. The Y2 receptor is found mainly in the central nervous system. NPY receptors are a member of the G protein-coupled receptor superfamily. |
| Gene ID | 4886 |
|---|---|
| Other Names | NPY1-R; NPYR; Y1-R; NPY-1; NPY1R_HUMAN; NPY1R; NPYY1; NPY1R_MOUSE; NPY1R_RAT; FC5; neuropeptide Y receptor Y1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NPY1R |
|---|---|
| Synonyms | NPYR, NPYY1 |
| Function | Receptor for neuropeptide Y (NPY) and peptide YY (PYY) (PubMed:1317848, PubMed:1321422, PubMed:35165283, PubMed:35507650, PubMed:38882210). Can also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form, while having virtually no affinity for pancreatic polypeptide (PP/PPY) at physiological concentrations (PubMed:1321422, PubMed:38882210). NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:1317848, PubMed:1321422, PubMed:35507650, PubMed:38882210). Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels (PubMed:1317848, PubMed:1321422, PubMed:35165283). As a receptor for NPY, it is involved in the regulation of eating behavior and NPY-induced stimulation of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Cat# AP98333
