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MKLP1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q02241 |
| Other Accession | Q02241 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 110059 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MKLP1 |
| Epitope Specificity | 221-310/960 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain. |
| SUBUNIT | Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed of RACGAP1 and KIF23. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. |
| Post-translational modifications | Ubiquitinated. Deubiquitinated by USP8/UBPY. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different isoforms. |
| Gene ID | 9493 |
|---|---|
| Other Names | CDA3; CDAIII; CDAN3; CDAN3A; CHO1; KNSL5; MKLP-1; MKLP1; 3110001D19Rik; KIF23_HUMAN; KIF23; Kinesin-like protein 5; Mitotic kinesin-like protein 1; kinesin family member 23; kinesin-like 5 (mitotic kinesin-like protein 1) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KIF23 |
|---|---|
| Synonyms | KNSL5, MKLP1 |
| Function | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody, Midbody ring. Midbody. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis |
| Tissue Location | Widely expressed.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98341
