癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MTRF1L Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9UGC7 |
| Other Accession | Q9UGC7 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Human, Rabbit, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43600 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MTRF1L |
| Epitope Specificity | 301-380/380 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the prokaryotic/mitochondrial release factor family. |
| Post-translational modifications | Methylation of glutamine in the GGQ triplet is conserved from bacteria to mammals. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Mitochondrial DNA encodes 13 proteins that play essential roles in the respiratory chain, while all proteins involved in mitochondrial translation are encoded by nuclear genes that are imported from the cytoplasm. MTRF1L is a nuclear-encoded protein that functions as a releasing factor that recognizes termination codons and releases mitochondrial ribosomes from the synthesized protein (summary by Nozaki et al., 2008 [PubMed 18429816]).[supplied by OMIM, Nov 2010] |
| Gene ID | 54516 |
|---|---|
| Other Names | HMRF1L; MRF1L; mtRF1a; RF1ML_HUMAN; MTRF1L; Mitochondrial translational release factor 1-like; mitochondrial translation release factor 1 like; mitochondrial translational release factor 1 like |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MTRF1L (HGNC:21051) |
|---|---|
| Function | Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG. |
| Cellular Location | Mitochondrion. |
| Tissue Location | Expressed in skeletal muscle (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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