癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
phospho-GNA12 (Ser40) Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q03113 |
| Other Accession | Q03113 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44279 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GNA12 |
| Epitope Specificity | RR(p-S)RD |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the G-alpha family. G(12) subfamily. |
| SUBUNIT | G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Guanine nucleotide-binding proteins (G proteins) are modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 subunits; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. |
| Gene ID | 2768 |
|---|---|
| Other Names | HG1M1; NNX3; RMP; gep; Galpha12; GNA12_HUMAN; GNA12; G alpha-12; G-protein subunit alpha-12; GNA12_MOUSE; Gna-12; GNA12_RAT; G protein subunit alpha 12; guanine nucleotide binding protein (G protein) alpha 12; GNA12 (phospho-S40); p-GNA12; phospho-GNA12; GNA12 (phospho-Ser40) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GNA12 |
|---|---|
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12515866, PubMed:15240885, PubMed:15525651, PubMed:16705036, PubMed:16787920, PubMed:17565996, PubMed:22609986, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:12515866, PubMed:15240885, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production (PubMed:16705036, PubMed:16787920, PubMed:23762476, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). |
| Cellular Location | Cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63210}; Cytoplasmic side {ECO:0000250|UniProtKB:Q63210}. Lateral cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63210}; Cytoplasmic side {ECO:0000250|UniProtKB:Q63210}. Cytoplasm. Note=Associated to the plasma membrane via lipid-anchor (By similarity). CDH1 enhances cell membrane localization (PubMed:15525651). {ECO:0000250|UniProtKB:P27600, ECO:0000269|PubMed:15525651} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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