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LRCH4/LRRN1 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O75427 |
| Other Accession | O75427 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 73450 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LRCH4 |
| Epitope Specificity | 31-130/683 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 CH (calponin-homology) domain.Contains 9 LRR (leucine-rich) repeats. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Members of the leucine-rich repeat family include LRCH1, LRCH2, LRCH3 and LRCH4. All family members contain one calponin-homology domain and nine leucine-rich repeats. LRCH4 (leucine-rich repeats and calponin homology (CH) domain containing 4), also known as LRN, LRRN1, LRRN4 or SAP25, is a 683 amino acid protein that belongs to the leucine-rich repeat family. The carboxy-terminus of LRCH4 may act as a membrane anchor between cells, while the amino-terminus contains the leucine-rich domains, which is thought to be involved in ligand binding. The calponin homology (CH) domain is suggested to confer Actin binding to a variety of cytoskeletal and signaling molecules. The gene encoding LRCH4 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. |
| Gene ID | 4034 |
|---|---|
| Other Names | LRN; LRRN1; LRRN4; PP14183; 2810008P14Rik; 2900069C24Rik; SAP25; LRCH4_HUMAN; LRCH4; Leucine-rich repeat neuronal protein 4 (Leucine-rich neuronal protein); LRCH4_MOUSE; leucine rich repeats and calponin homology domain containing 4; leucine-rich repeats and calponin homology (CH) domain containing 4 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LRCH4 (HGNC:6691) |
|---|---|
| Synonyms | LRN, LRRN1, LRRN4 |
| Function | Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q921G6}; Single-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98366
