癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
INSM2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q96T92 |
| Other Accession | Q96T92 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 59491 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human INSM2 |
| Epitope Specificity | 401-500/566 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 5 C2H2-type zinc fingers. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | INSM2 is a 566 amino acid nuclear protein. INSM2 is believed to act as a growth or tumor suppressor in certain neurons and in liver cells. INSM2 contains five zinc finger C2H2-type domains which bind nucleic acids. Zinc fingers are composed of 25-30 amino acid residues and have the ability to bind about five nucleotides. C2H2-type zinc fingers have two cysteines on one extremity of the domain, and two histidines on the other extremity. These four cysteines and histidines interact with one zinc atom, resulting in the finger-like conformation of the domain. It is believed that the C2H2-type zinc fingers require the binding of a zinc atom in order for the finger to bind DNA or RNA. |
| Gene ID | 84684 |
|---|---|
| Other Names | IA-6; IA6; mlt1; INSM2_HUMAN; INSM2; Zinc finger protein IA-6; INSM2_MOUSE; Methylated in liver tumor 1; INSM transcriptional repressor 2; insulinoma-associated 2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | INSM2 |
|---|---|
| Synonyms | IA6 |
| Function | May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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¥ 1,250.00
Cat# AP98373
