癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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ZDHHC13/HIP14L Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8IUH4 |
| Other Accession | Q8IUH4 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 70861 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ZDHHC13/HIP14L |
| Epitope Specificity | 501-600/622 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. Contains 6 ANK repeats. Contains 1 DHHC-type zinc finger. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ZDHHC13 is a 622 amino acid multi-pass membrane protein that contains one DHHC-type zinc finger and six ANK repeats. Expressed as multiple alternatively spliced isoforms, HIP14L functions as a palmitoyltransferase that catalyzes the conversion of palmitoyl-CoA and a protein-cyeteine to an S-palmitoyl protein and CoA and, via this catalytic activity, may be involved in the NFⅹB signaling pathway. The gene encoding HIP14L maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. |
| Gene ID | 54503 |
|---|---|
| Other Names | HIP14L; HIP3RP; 2410004E01Rik; C530010M18; kojak; skc4; DHHC-13; fi22e09; wu:fb06e01; wu:fc39g10; wu:fi22e09; zgc:101690; ZDH13_HUMAN; ZDHHC13; Huntingtin-interacting protein 14-related protein (HIP14-related protein); Huntingtin-interacting protein HIP3RP; Putative MAPK-activating protein PM03; Putative NF-kappa-B-activating protein 209; Zinc finger DHHC domain-containing protein 13 (DHHC-13); 2.3.1.225; ZDH13_MOUSE; zDHHC palmitoyltransferase 13; zinc finger DHHC-type containing 13; zinc finger DHHC-type palmitoyltransferase 13 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ZDHHC13 (HGNC:18413) |
|---|---|
| Function | Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (By similarity). Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport. |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9CWU2}; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9CWU2}; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles. {ECO:0000250|UniProtKB:Q9CWU2} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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