癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KIST Rabbit pAb
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8TAS1 |
| Other Accession | Q8TAS1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 46546 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KIST/UHMK1 |
| Epitope Specificity | 331-419/419 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Contains 1 protein kinase domain.Contains 1 RRM (RNA recognition motif) domain. |
| SUBUNIT | Interacts with stathmin and CDKN1B/p27Kip1 (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. |
| Gene ID | 127933 |
|---|---|
| Other Names | KIS; KIST; P-CIP2; 4732477C12Rik; 4930500M09Rik; C820018A03Rik; UHMK1_HUMAN; UHMK1; Kinase interacting with stathmin; PAM COOH-terminal interactor protein 2 (P-CIP2); U2AF homology motif kinase 1; 2.7.11.1; UHMK1_MOUSE; UHMK1_RAT; U2AF homology motif (UHM) kinase 1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | UHMK1 |
|---|---|
| Synonyms | KIS, KIST |
| Function | Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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